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Various Cellular and Molecular Axis Involved in the Pathogenesis of Asthma

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Targeting Cellular Signalling Pathways in Lung Diseases

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Abstract

Asthma is a chronic inflammatory disease described by impaired lung function, airway hyperresponsiveness, episodic wheezing, and dyspnea. Asthma prevalence has risen drastically, and it is estimated that more than 339 million individuals worldwide had asthma with marked heterogeneity in pathophysiology and etiology. Several factors involved in the progression and development of asthma include allergens, pollutants, obesity, viruses, antigens, and many more, eliciting strong inflammatory and immune responses, causing airflow obstruction, and tightening of respiratory smooth muscle causing the characteristic asthma symptoms. Multiple complex molecular pathways are involved in asthma pathophysiologies such as immunoglobulin E, cytokines, nitric oxide, dendritic cells, leukotrienes, oxidative stress, and inflammatory infiltrate of mast cells, neutrophils, eosinophils, lymphocytes, innate immunity, and many more. The current chapter focuses on illustrating the various molecular pathways that contribute to asthma development and its progression.

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Authors and Affiliations

  1. Department of Medical lab Technology, University Institute of Applied Health Sciences, Chandigarh University, Mohali, Punjab, India

    Gurjit Kaur Bhatti

  2. Centre for Biomedical Engineering (CBME), Indian Institute of Technology (IIT), Delhi, India

    Amit Khurana

  3. Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science (CVSc), PVNRTVU, Hyderabad, Telangana, India

    Amit Khurana

  4. Department of Pharmacology, Central University of Punjab, Bathinda, India

    Debapriya Garabadu

  5. Department of Pharmacology, Shree S K Patel College of Pharmaceutical Education and Research, Mehsana, Gujrat, India

    Prashant Gupta

  6. Department of Biotechnology, National Institute of Pharmaceutical Education and Research, S.A.S. Nagar, Punjab, India

    Snehal Sainath Jawalekar

  7. Department of Human Genetics and Molecular Medicine, School of Health Sciences, Central University of Punjab, Bathinda, India

    Jasvinder Singh Bhatti

  8. Department of Pharmacology, School of basic and applied Sciences, Central University of Punjab, Bathinda, India

    Umashanker Navik

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  1. Graduate School of Health, Discipline of Pharmacy, University of Technology Sydney, Sydney, NSW, Australia

    Kamal Dua

  2. Drug Development and Innovation Centre, University of Alberta, Edmonton, AB, Canada

    Raimar Löbenberg

  3. Haematology and Hemotherapy Center, State University of Campinas, Campinas, São Paulo, Brazil

    Ângela Cristina Malheiros Luzo

  4. Graduate School of Health, Discipline of Pharmacy, University of Technology Sydney, Sydney, NSW, Australia

    Shakti Shukla

  5. School of Pharmaceutical Sciences & Division of Research & Development, Lovely Professional University, Phagwara, Punjab, India

    Saurabh Satija

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Bhatti, G.K. et al. (2021). Various Cellular and Molecular Axis Involved in the Pathogenesis of Asthma. In: Dua, K., Löbenberg, R., Malheiros Luzo, Â.C., Shukla, S., Satija, S. (eds) Targeting Cellular Signalling Pathways in Lung Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-33-6827-9_3

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