TPIR-785 Raman – Highest-Sensitivity Raman Spectrometer

02/03/2020

Why NIR Raman?

Benefits

Autofluorescence from biological specimens introduces severe interference to UV/VIS Raman
spectral data and obscures the analysis results.
Working with longer-wavelength excitation lasers (e.g., 785 nm and 830 nm) can reduce or
eliminate the fluorescence background. Longer-wavelength light penetrates much deeper
than UV/VIS light. Raman spectral data generated using NIR lasers provides the biochemical
information needed to perform the most accurate subcutaneous, tissue, and tumor analysis.

Why is a highly sensitive spectrometer an
absolute requirement for NIR Raman?

Challenges

Raman signal strength decreases with longer-wavelength excitation lasers because the
spontaneous Raman scattering cross-section is proportional to 1/λ4. Furthermore, highly
photosensitive biological samples prohibit the use of higher-power lasers.
The sensitivity of conventional CCD sensors starts to decrease significantly in the NIR spectral
region. In contrast, InGaAs sensors afford better coverage in the NIR but lack sensitivity from
700 nm to 1000 nm and suffer from much higher dark noise than silicon-based sensors.
Teledyne Princeton Instruments has been providing limitation-shattering cameras and
spectrographs to the research community for decades. Now, with the TPIR-785 Raman, we
have combined myriad leading-edge technological innovations to build our first truly integrated
Raman spectrometer.