First Goatse is a Flickr group dedicated to documenting people's first reactions to Goatse.cx. Since we don't want to be responsible for your first Goatse, let me just point out that involves a man pulling his gaping anus so far apart that you can see the contents of his colon through the veiny pulsing tunnel, so don't Google Image 'Goatse.cx' up.
Laughing Squid reports that someone managed to First Goatse the entirety of the San Francisco Apple Store:
Awesome. I'd love to see this become an entire guerilla style movement. My first Goatse... at IMAX! My first Tub Girl... in Times Square!